A paper to discuss today: Zhao, Y., Schultz, N. E., Truhlar, D. G., Design of Density Functionals by Combining the Method of Constraint Satisfaction with Parametrization for Thermochemistry, Thermochemical Kinetics, and Noncovalent Interactions. J. Chem. Theory Comput. 2(2), 364-382 (2006) (https://doi.org/10.1021/ct0502763)